Myocardial Injury, Perioperative Complication
Conditions
Keywords
Non cardiac surgery
Brief summary
Myocardial injury after noncardiac surgery (MINS) is common, silent, and strongly associated with morbi-mortality. There are some evidences in the littérature showing that troponin elevation pre and/or postoperatively and surgical Apgar score are strongly and independently associated with postoperative morbi-mortality. In this cohort study of orthopedic surgery patients (\> 50years), the aim is to determine MINS incidence and to assess wich peri-operative factors are associated with the occurrence of MINS. The final objective is to create a score to better identified the patients with a MINS and a poor outcome.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* \> 50 years * orthopedic surgery (hip, knee, spine) * written consent
Exclusion criteria
* no troponin measurement prior surgery * sepsis * acute coronary syndrome * pulmonary embolism * refusing to participate * guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative MINS incidence | 3 days after surgery | Troponin elevation \> 5ng/l compared to previous measurement OR troponin elevation \> 65 ng/l |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with an episode of acute pulmonary oedema | 3 months | Acute pulmonary oedema |
| Number of Participants with coronary angioplasty | 3 months | Coronary angioplasty |
| Number of Participants with myocardial infarction | 3 months | Myocardial infarction |
| Number of Participants with stroke | 3 months | Stroke |
| Number of Participants with cardiac arrest | 3 months | Cardiac arrest |
| Mortality rate | 3 months | Death |
| Revised Cardiac Risk Index for Pre-Operative Risk (Lee score) | Inclusion | Minimum value = 0 Minimum value = 0, maximum value = 6, higher scores mean a worse outcome (higher peri operative mortality risk) |
| Metabolic Equivalent of Task (MET) | Inclusion | Minimum value = 1, Maximum value= 10, a low score (MET \<4) is associated with a capacity to do some light intensity activities and is associated with cardiovascular risk. |
| Number of Participants with transient stroke | 3 months | Transient stroke |
Countries
France
Contacts
Primary ContactOlivier HUET, MD,PhD
Backup ContactAnaïs CAILLARD, MD
Outcome results
None listed