Dystonia, Essential Tremor, Parkinson Disease
Conditions
Brief summary
In this research study the researchers want to learn more about brain activity related to speech perception and production.
Detailed description
Speech production is disrupted in a number of neurological diseases that involve the basal ganglia, including Parkinson's disease (PD) and dystonia. The investigators will use a novel experimental approach and combination of analytic techniques to elucidate the contribution of neural activity in cortical-basal ganglia circuits to the hierarchical control of speech production, in subjects undergoing deep brain stimulation surgery.
Interventions
OTHERelectrophysiological data collection
Electrophysiological data collection at the time of DBS surgery.
Sponsors
Massachusetts General Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. Subjects scheduled for DBS implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of Parkinson's disease, essential tremor or dystonia. 2. Subjects able to provide informed consent and comply with task instructions. 3. Subjects 18-85 years old
Exclusion criteria
1. Subjects with reported hearing loss. 2. Non-English-speaking subjects
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The number of subjects providing the interpretable speech related electrophysiological data collection. | Duration of single DBS surgery | The number of subjects providing the interpretable speech related electrophysiological data during DBS surgery. |
Countries
United States
Contacts
CONTACTMark Richardson, MD, PhD
CONTACTErin Donahue, PhD
Outcome results
None listed