Anesthesia, Anesthesia; Adverse Effect
Conditions
Keywords
General anesthesia, Propofol, Sevoflurane, Co-induction, Laryngeal mask airway
Brief summary
Co-induction technique refers to the use of a combination of medications to reach the desired therapeutic target. In the present study, the investigators examined the safety of a novel co-induction approach that relied on a simple timing and dosing alterations to the classical approaches of inhalational sevoflurane and propofol induction. The significance of this study is to find a reliable safe alternative method of induction that can provide optimal parameters,when compared to the classical methods of induction.
Detailed description
Co-induction technique refers to the use of a combination of medications to reach the desired therapeutic target. This technique is considered an approach that can be of a great benefit to patients with chronic medical illnesses and those who have moderate to high risk for general anaesthesia. In the present study, the investigators examined the safety of a novel co-induction approach that relied on a simple timing and dosing alterations to the classical approaches of inhalational sevoflurane and propofol induction. The significance of this study is to find a reliable safe alternative method of induction that can provide optimal parameters,when compared to the classical methods of induction. The investigators evaluated the time needed for laryngeal mask airway (LMA) insertion, number of LMA insertion trials, succession of LMA insertion, adverse events related to the airway, respiratory and cardiovascular systems, haemodynamic stability and satisfaction scores of enrolled patients.
Interventions
DRUGInduction using propofol
Patients were given 1.5 mcg/Kg of fentanyl intravenously. two minutes after the fentanyl dose, a dose of 1.5 mg/kg of propofol slowly over 2 minutes.
DRUGInduction using sevoflurane
Patients were given 1.5 mcg/Kg of fentanyl intravenously. two minutes after the fentanyl dose, patient received 8% inhalational sevoflurane through sealed plastic face mask at 8 L/min flow of oxygen.
DRUGInduction using propofol and sevoflurane
Patients were given 1.5 mcg/Kg of fentanyl intravenously. two minutes after the fentanyl dose, patient received 4% sevoflurane through sealed plastic face mask at 8 L/min flow of oxygen for 2 minutes, followed by a dose of 0.75 mg/kg of propofol given slowly.
Sponsors
University of Jordan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* patients with Age ≥ 65 years. * American Society of Anaesthesiologists' (ASA) score II or III. * minimally invasive endoscopic urological procedures.
Exclusion criteria
* patient refusal. * Age \< 65 years. * family history of malignant hyperthermia. * prolonged surgery that needed intubation. * body mass index (BMI) \> 35 kg/m2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative respiratory adverse events | 8 months | The investigators recorded the occurrence of transient apnea intraoperatively, in addition to laryngeal spasm, coughing, gagging and increased salivation. The study chart included the documentation these common adverse events, the timing of occurrence, and the intervention required to manage these events. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time for successful laryngeal mask airway insertion | 8 months | The investigators assessed the time needed for LMA insertion. The timer was started upon giving the fentanyl, recording the time till successful insertion of laryngeal mask airway. |
| Blood pressure stability | 8 months | The investigators recorded patients' blood pressure readings throughout the induction procedure. |
| Heart rate stability | 8 months | The investigators recorded patients' heart rate throughout the induction procedure. |
| Changes in oxygen saturation | 8 months | The investigators recorded patients' oxygen saturation throughout the induction procedure. |
Countries
Jordan
Outcome results
None listed