Influenza
Conditions
Brief summary
Multicapillary Ion mobility spectrometry of nasal air aspirates shall be investigated as screening tool for the detection of Influenza and SARS-CoV-2- infection.
Detailed description
Bacterial infections can be distinguished by analysis of the volatile organic compounds found in breath. In patients with suspected Influenza infection, nasal air samples will be taken and analyzed by Multicapillary Ion mobility spectrometry (MCC IMS). Routinely all patients undergo polymerase chain reaction (PCR) analysis of nasopharyngeal swabs for Influenza. MCC IMS spectra will be compared between infected and non infected patients by cluster analysis and discrimination analysis. If the number of infected patients exceeds 50 an additional validation cohort will be investigated sequentially otherwise validation will be performed during the Influenza epidemic 2021. Due to decreasing numbers of Influenza-A- Infections study was opened to also include patients with suspected SARS-CoV-2 infections.
Interventions
DIAGNOSTIC_TESTMCC IMS
Diagnosis by MCC IMS
Sponsors
Klinikum Bayreuth GmbH
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* suspected Influenza infection
Exclusion criteria
* later than 48h after admission and detection of Influenza infection * later than 32 days after admission and detection of SARS-CoV-2- infection * no written consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cluster Analysis of MCC IMS spectra. | immediatly after sampling | Cluster Analysis of MCC IMS spectra will be obtained immediately after sampling |
Countries
Germany
Outcome results
None listed