End-Tidal Carbon Dioxide, Ventilation
Conditions
Keywords
End-Tidal Carbon Dioxide, P(a-ET)CO2 gradient, ETCO2, low tidal volüm, mekanical Ventilation
Brief summary
In cases where there is no ventilation-perfusion problem, the end-tidal carbon dioxide (ETCO2) value is closely associated with partial arterial carbon dioxide pressure (PaCO2); therefore, the PaCO2 value can be estimated using ETCO2 measurements in patients without significant cardiopulmonary disorders. The aim of the investigator's study is to evaluate the reliability of pulmonary ventilation monitoring with ETCO2 value and to investigate at what tidal volume values ETCO2 monitoring provides reliable information.
Detailed description
The patients were grouped as follows: Group 1, if the tidal volume is 4 ml/kg; Group 2, if TV=6 ml/kg; Group 3, if TV=8 ml/kg; and Group 4, if TV=10 ml/kg. It was determined how many breaths per minute (minute ventilation) would be given with tidal volume x respiratory rate=6 L. The patients were ventilated with the same ventilation parameters for 30 minutes and then arterial blood gas analysis was performed. Arterial blood gas was collected at t1 for group 1, t2 for group 2, t3 for group 3, and t4 for group 4. The ETCO2 value, Peak pressure (Ppeak), Plateau pressure (Pplato), mean airway pressure (Pmean) values were recorded at the time of arterial blood gas collection. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), peak heart rate (PHR) values were evaluated. The patients with a mean arterial pressure of less than 65 mmHg were excluded from the study. Partial arterial oxygen pressure (PaO2), partial arterial carbon dioxide pressure (PaCO2), oxygen saturation (SO2) values were recorded from the arterial blood gas analysis. P (a-ET) CO2 gradient value was calculated. The groups were compared, in each patient, under the same conditions, when the different tidal volume was applied, how the ETCO2 monitorization, PaO2 values and hence the P (a-ET) CO2 gradient changed.
Interventions
OTHERif the ventilation parameter caused desaturation or hypercapnia we will change the parameter
we will increased fi02
Sponsors
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Double
Intervention model description
sequential
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
American Society of Anesthesiologists (ASA) classification 1, 2 risk group Head and neck surgery under general anesthesia lasting more than 120 minutes and who progressed normotensive.
Exclusion criteria
Cardiac disease Pulmonary disease Obese patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| P (a-ET) CO2 gradient | 120 minutes | The groups were compared, in each patient, under the same conditions, when the different tidal volume was applied, how the ETCO2 monitorization, PaCO2 values and hence the P (a-ET) CO2 gradient changed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Partial arterial oxygen pressure (PaO2) | 120 minutes | Partial arterial oxygen pressure (PaO2) were recorded from the arterial blood gas analysis |
Countries
Turkey (Türkiye)
Outcome results
None listed