Autoimmune Enteropathy, Celiac Disease, Inflammatory Bowel Diseases
Conditions
Keywords
Celiac Disease, Autoimmune enteropathy, Primary immunodeficiency, Intestinal lymphoma, Liver autoimmune diseases
Brief summary
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
Interventions
GENETICBlood sample collection; gastrointestinal biopsy
Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage...
Sponsors
Imagine Institute
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years or over * affiliated to social insurance * signed informed consent
Exclusion criteria
* pregnancy * under guardianship * not able to sign informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intestinal Lymphocytes count | Baseline | Lymphocytes isolation |
| DNA sequencing | Baseline | Targeted Next Generation sequencing |
Countries
France
Contacts
Primary ContactGeorgia MALAMUT, MD, PhD
Backup ContactAnaïs LEVESCOT, MD, PhD
Outcome results
None listed