Executive Function Disorders, Learning Disorders, Schizophrenia
Conditions
Keywords
learning disorders, executive function disorders, psychosis, children, adult-age
Brief summary
The primary objective of the study aims to study transition toward schizophrenia in patients with learning disorders, and to compare the risk between patients with specific learning disorders, and patients with complexed learning disorders (by two types: patients with other neuro-developmental disorders including executive function disorders, and patients with anxiety).
Detailed description
As secondary objectives, the study aims to: * argue the clinical predicted markers (neuropsychological) transition toward psychosis. * test the feasibility and the acceptability of a early diagnosis for a potential applicable guidance for different referent centers of learning in French territory. * have a better classification of patients with learning disorders in order to target a prospective primary prevention of risk of psychosis via the questionnaires (AQ of Baron-Cohen: Autism-spectrum quotient auto-questionnaire; Inventory of Beck Anxiety Inventory, auto-questionnaire for panic disorder and general anxiety; Liebowitz Social Anxiety Scale). * improve identification of the early signs and the early emerging psychological diseases intervention management (schizophrenia). * Psychic disability: prevent and reduce non-seeking care and accompaniment situations, and risk of rupture of care. * permitting better care of psychosocial rehabilitation with cognitive evaluation. This study will be conducted in Centre de référence des troubles du langage et des apprentissages, Hôpital Raymond Poincaré, APHP, in France.
Interventions
DIAGNOSTIC_TESTStandardised semi-structured talk
Comprehensive assessment of at-risk mental states (CAARMS) will be used.
DIAGNOSTIC_TESTAutistic spectre disorder screening
Autism-spectrum quotient (AQ) auto-questionnaire will be used.
DIAGNOSTIC_TESTAnxiety measuring
An inventory for measuring clinical anxiety: Beck Anxiety Inventory (BAI); Liebowitz Social Anxiety Scale.
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 30 Years
Healthy volunteers
No
Inclusion criteria
* Patients born between 1990 and 2005, have been cared by Dr Schlumberger in 2014 in the center of language and learning disorders at Raymond Poincaré hospital; * With severe learning disorders: deficiency in school work, need at least one medical appointment and long-term rehabilitation in the center of language and learning disorders at Raymond Poincaré hospital; * Affiliated to a social protection schema; * Written informed consent signed.
Exclusion criteria
* Absence of learning disorder; * Intellectual deficiency; * Epilepsia; * Patients who will performed follow-up at Chartres city; * Patients under guardianship or curatorship; * Foreign patients under AME schema, a medical help from the state in France.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Semi-structured interview | At baseline | Assessement with Comprehensive Assessment of At-Risk Mental States (CAARMS) during 6 to 90 minutes at the center of Raymond Poincaré hospital. The unique collection during the interview, quotation of each patient will be given from the assessement. There will be 4 groups by the results: CAARMS negative subjects, vulnerable subjects, attenuated psychosis subjects and subjects with brief and limited intermittent psychotic syndrome. The further statistic comparison will be done between the 3 last groups classified with results of CAARMS. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Autistic screening | At baseline | Autism-spectrum quotient (AQ) auto-questionnaire will be used to evaluate difficulty in social interaction. |
| Anxiety measuring | At baseline | An inventory for measuring clinical anxiety: Beck Anxiety Inventory |
| Social interaction difficulty evaluation | At baseline | Liebowitz Social Anxiety Scale as questionnaire |
Countries
France
Outcome results
None listed