LARS in Ovarian Cancer Patients

Low Anterior Resection Syndrome (LARS) in Ovarian Cancer Patients - a Multi-centre Comparative Analysis.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04279080

Enrollment

125

Registered

2020-02-20

Start date

2003-01-01

Completion date

2018-12-31

Last updated

2020-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low Anterior Resection Syndrome

Brief summary

Background: Low anterior resection syndrome (LARS) is a common functional disorder after low anterior resection impacting quality of life. Data on LARS derives nearly exclusively from rectal cancer studies. Therefore, the study was designed to assess LARS in advanced epithelial ovarian cancer (EOC) patients, who underwent rectal resection and to compare it with a female rectal cancer cohort. Methods: A cross-sectional multi-centre analysis was performed for female patients suffering from either rectal or EOC who received a low anterior resection as part of their therapy regimen. None of the patients received pre- or postoperative radiotherapy. LARS was defined by using the validated LARS score and its severity was divided into no, minor and major LARS.

Interventions

OTHERlow anterior resection syndrome evaluation

evaluation of postoperative functional bowel outcome

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Inclusion criteria

* low anterior resection because of ovarian or rectal cancer

Exclusion criteria

* neoadjuvant or adjuvant radiotherapy

Design outcomes

Primary

Measure	Time frame	Description
functional bowel outcome after low anterior resection	1 year	low anterior resection syndrome score, questionnaire via telephone call or personal contact

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026