Acute Coronary Syndrome, Cognitive Impairment, Elderly
Conditions
Brief summary
This study aims to investigate the incidence and characteristics of cognitive Impairment(CI) in the elderly patients with acute coronary syndrome (ACS), and to determine whether CI are predictive of the prognosis of major adverse cardiovascular events (MACE) and mortality.
Interventions
DIAGNOSTIC_TESTMMSE and MoCA
This is an observational study. All the patients evaluate with MMSE (Mini-mental State Examination) and MoCA (Montreal Cognitive Assessment), and investigate the incidence and characteristics of cognitive and MACE
Sponsors
Beijing Friendship Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥65yr * Confirmed ACS diagnosis （include unstable angina, ST-segment elevation myocardial infarction and Non ST-segment elevation myocardial infarction） * fulfilled MMSE or MoCA * patients agreed and provided informed consent
Exclusion criteria
* Type 2 myocardial infarction and Acute nonischemic myocardial injury * past history of malignant tumors * Past history of stroke or dementia * Hepatic insufficiency (ALT\>8ULN or ALT\>3ULN and TBIL\>2ULN) * Renal insufficiency (GFR\<15 ml/min/1.73m2)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MACE (major adverse cardiovascular events) | 12 months | Myocardial infarction, revascularization, stroke, cardiac death, all cause of death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive level decline | 12 months | Evaluate with MMSE (Mini-mental State Examination) |
Countries
China
Contacts
Primary ContactHongwei Li, Prof.
Outcome results
None listed