The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney

The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney: A Double Blind Randomized Placebo-controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04278495

Enrollment

Registered

2020-02-20

Start date

2014-09-01

Completion date

2018-12-01

Last updated

2020-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Losartan Adverse Reaction, Uropathy, Uropathy Obstructive

Brief summary

Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction. Nevertheless, these witnessed effects have not been yet translated into the clinical practice.

Interventions

DRUGCozaar (Losartan Potassium 25mg)

Cozaar (Losartan Potassium 25mg)

DRUGPlacebo

Placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* anuric and oliguric patients * calculuar ureteral obstruction

Exclusion criteria

* anomalous kidney * bilateral obstructed kidney * history of recent use of angiotensin receptor blockers or angiotensin-converting enzyme inhibitors * ASA score of \>3

Design outcomes

Primary

Measure	Time frame	Description
Renographic glomerular filtration rate of the affected kidney.	3 months	assessed by radioisotope renography using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) in ml/min

Secondary

Measure	Time frame	Description
Serum creatinine change	3 months	assessed by serum creatnine in mg/dl

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026