Mild Cognitive Impairment
Conditions
Keywords
AD EEG OCT biomarker
Brief summary
Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Meantime, EEG resting state has also demonstrated significant change in patients with AD in neuroscience research area. Thus, the combination of these sensitive biomarkers would lead to a potential new biomarker for detection of AD, which has higher specificity and sensitivity.
Interventions
DIAGNOSTIC_TESTobservational
No intervention
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-sen University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of Alzheimer's Disease
Exclusion criteria
* neurologic disorders * psychiatric disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| OCT retinal and choroidal thickness | 2 days | retinal structural anatomy |
| Retinal Photography vascular caliber | 2 days | use Retinal Photography to detect vascular caliber |
| functional connection strength in the brain network | 7 days | record resting-state EEG, use graph theory to calculate the functional connection strength |
Countries
China
Contacts
Primary ContactJin Yuan, phD
Backup ContactLi Gu, phD
Outcome results
None listed