Acute Ischemic Stroke
Conditions
Brief summary
Intravenous thrombolysis is recommended within 4.5 hours of stroke onset. The aim of the study is to evaluate whether a hypodensity on native CT within the virtually entire area of hypoperfusion on perfusion CT, i.e. hypoperfusion-hypodensity mismatch, identifies patients within the time window of thrombolysis in a multicenter cohort. The investigators hypothesize hypoperfusion-hypodensity mismatch will identify patients ≤ 4,5 hours of symptom onset with \>70% specificity and \>85% positive predictive value.
Interventions
DIAGNOSTIC_TESThypoperfusion-hypodensity mismatch
hypoperfusion-hypodensity mismatch on computed tomography
Sponsors
University Hospital Muenster
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* acute ischemic stroke * evidence of acute intracranial vessel occlusion (any supratentorial proximal or peripheral artery of the anterior cerebral artery, middle cerebral artery or posterior cerebral artery territory) by CT hyper dense thrombus and/or CTangiography vessel occlusion and/or by ischemic perfusion deficit * evidence for acute ischemic perfusion deficit, i.e. acute symptoms attributable to ischemic CT perfusion lesion * complete native CT and CTperfusion performed on admission * sufficient CT and CTperfusion quality for judgement of acute ischemic hypodensity * known time of symptom onset.
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive predictive value of hypoperfusion hypodensity mismatch for the identification of patients ≤4.5 hours | on admission |
| Specificity of hypoperfusion hypodensity mismatch for the identification of patients ≤4.5 hours | on admission |
Countries
Germany
Outcome results
None listed