Stroke, Stroke Sequelae
Conditions
Keywords
fatigue, fatigability, functional impairment
Brief summary
Post-stroke fatigue is highly prevalent and disabling. However, its causes and consequences in the chronic phase are not fully understood. The aim of this cross-sectional study is to explore functional correlates of post-stroke fatigue in the chronic phase.
Interventions
None listed
Sponsors
Centre Hospitalier Universitaire UCLouvain Namur
CHU Ambroise-Paré - Mons
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Mini Mental State Evaluation \> 24 * Stroke \> 6 months ago
Exclusion criteria
* Current active infection * Multiple stroke * Other affection of the central nervous system * Medication potentially inducing severe fatigue * Hospital admission during last month * Severe Apraxia * Severe Aphasia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fatigue Severity Scale (FSS) | assessment during 1 day study visit | 9-item fatigue scale (Score/7) Minimum value = 1, Maximum value = 7 An average score greater than or equal to four signifies pathological fatigue |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 6-minute walk test | assessment during 1 day study visit | Speed decrement (distance first minute - distance last minute). The distance walked each minute and the total distance walked were measured. Performance fatigability was assessed by the difference of distance walked during the first and sixth minutes. |
| Pittsburgh Sleep quality index | assessment during 1 day study visit | Sleep assessment. The score of seven components are summed to provide a global score from 0 to 21. A global score greater than five is indicative of poor sleep |
| ACTIVLIM specific to patients with stroke | assessment during 1 day study visit | Rasch-validated activity assessment. Self-report 20-item questionnaire based on the International Classification of Functioning, Disability and Health and includes activities related to self-care, transfer, mobility, manual ability and balance. Participants have to evaluate the perceived difficulty of performing each activity if realised without technical or human assistance. Each item has three response possibilities (impossible, difficult, easy) |
| Hospital Anxiety and Depression Scale (HADS) | assessment during 1 day study visit | Mood assessment. Self-report questionnaire with anxiety and depression subscales, each consisting of 7 questions. Score each item from 0 (no symptoms) to 3 points (maximum impairment) The cutoff for a pathological score is ≥ 7 for each subscale |
| Neuromuscular Fatigability Index | assessment during 1 day study visit | Decrement in isometric strength of knee extensors during fatiguing task The NMFI is calculated by the difference between the putative torque-versus-time curve if the subject had maintained the maximal torque recorded during the first 5 seconds for 45 seconds, considered as a score of 100 arbitrary units, and the actual area under the torque-versus-time curve. A higher NMFI score indicates higher fatigability |
Countries
Belgium
Contacts
Primary ContactThierry Lejeune, MD
Outcome results
None listed