Effects of Ten-Weeks Power Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis

Effects of Ten-Weeks Resistance Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04276324

Enrollment

Registered

2020-02-19

Start date

2020-03-10

Completion date

2020-10-15

Last updated

2020-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Brief summary

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Strength training has been shown to improve strength and mobility in persons with MS.

Interventions

OTHERResistance training

Ten weeks of resistance training

OTHERTesting sessions

Testing sessions

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* mild or moderate disability with clinical mild spastic-ataxic gait disorder. * stable phase of the disease.

Exclusion criteria

* Expanded Disability Status Scale (EDSS) \< 6. * relapsing disease within the preceding 12 months. * corticosteroid treatment within the last months before study inclusion.

Design outcomes

Primary

Measure	Time frame	Description
Maximal Voluntary Isometric Contraction of Knee Extension	Before the program training	—
Rate of Force Development	Before the program training	—
Central Activation Ratio	Before the program training	—
Spasticity	Before the program training	Pendulum test

Secondary

Measure	Time frame	Description
Walking speed	Before the program training	Test 10 m-walks
Sleep Quality	Before the program training	Karolinska Sleep Diary and Acelerometry
Static balance	Before the program training	Romberg Test with eyes open and closed. Analysis with force plates
Functional capacity	Before the program training	Sit to stand test
Heart Rate Variability	Before the program training	Sleeping Heart Rate Variability

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026