Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage

Dr. Pao-Lin Kuo (Department of Obstetrics and Gynecology

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04275674

Enrollment

Registered

2020-02-19

Start date

2017-08-01

Completion date

2023-07-31

Last updated

2022-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation, Obesity

Brief summary

The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation. Obesity is associated with an increased risk of recurrent miscarriage (RM), but the underlying mechanisms are unclear. Abnormal inflammasome activation was also identified in the endometrium of women who experienced RM. Given inflammasome activation has emerged as common pathophysiology in obesity-related disorder and RM, the investigators wonder whether inflammasome activation occurs in the uterine macrophages of obese women, and result in early reproductive failure.

Detailed description

pending

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

All women have conceived naturally without the aid of assisted reproductive technologies

Exclusion criteria

N/A

Design outcomes

Primary

Measure	Time frame	Description
Validity of inflammatory markers	1 Day	Use the levels of hsCRP and CA125 provides the information about inflammation.

Countries

Taiwan

Contacts

Primary ContactPao-Lin Kuo, MD

paolink@mail.ncku.edu.tw886-6-2353535

Backup ContactPL Kuo, MD