Coagulation Disorder, Traumatic Brain Injury
Conditions
Keywords
Traumatic Brain Injury, Coagulation Disorder, Lipid Peroxidation
Brief summary
The purpose of this study is to observe the relationship between the level of lipid peroxidation products in serum of patients with traumatic brain injury and secondary coagulation disorders.
Detailed description
Uncontrolled hemorrhage after trauma is the leading cause of death. The mechanism of secondary coagulation dysfunction after trauma is special and complex, which has not been fully explained, leading to limited treatment and prevention methods. Coagulation disorders caused by traumatic brain injury is a systemic manifestation of local injury, which can activate platelets and promote platelet aggregation, activate thrombin, and promote the production of fibrin, leading to the formation of thrombosis. However, in non-injured areas, pro-coagulant molecules from damaged brain tissue reach the body through the broken blood-brain barrier, and also activate platelets and thrombin, promoting the formation of blood clots. Lipid peroxidation products are closely related to the occurrence of coagulation dysfunction. The effects lipid peroxidation products on platelets, thrombin and anticoagulant pathways may be a novel mechanism of secondary coagulation dysfunction in traumatic brain injury.
Interventions
None listed
Sponsors
Tang-Du Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. The interval between injury and admission is less than 24 hours 2. Age\>18yrs and age\<80yrs 3. Non-head abbreviated injury score \< 3 4. Did not undertake treatment before enrollment 5. Informed consent to participate in the study
Exclusion criteria
1. Take anticoagulants or antiplatelet drugs 2. Smoking history 3. Hemorrhagic or ischemic cerebrovascular disease occurred within six months 4. Other systemic diseases: uremia, cirrhosis, malignant tumor, etc 5. Patients with severe mental illness who are unable to communicate when diagnosed 6. Patients who refused follow-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The level of lipid peroxidation products in subjects' serum | within 24 hours of trauma | the level of high and low |
| Coagulation Disorders | within 24 hours of trauma | aPTT\>40s or INR\>1.4 or \<100 platelets per L |
Secondary
| Measure | Time frame |
|---|---|
| The 24-hour and 3-month Glasgow outcome score (GOS) | from onset to three months |
Countries
China
Contacts
Primary ContactWenxing Cui, M.D
Outcome results
None listed