The Correlation Between Cotinine and Postoperative Acute and Chronic Pain After Hysterectomy

The Correlation Between the Cotinine Levels in Urine and Postoperative Acute and Chronic Pain in Open Abdominal Hysterectomy Patients

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04274673

Enrollment

158

Registered

2020-02-18

Start date

2019-12-01

Completion date

2020-05-15

Last updated

2020-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Pain, Acute Pain, Cotinine, Hysterectomy

Brief summary

It is known that there is an association between smoking and acute/chronic pain. But it is so difficult to assess this relation with asking questions to the patients in the preoperative period. Because of that we want to measure the levels of the cotinine in the urine and later assess the correlation with acute and chronic pain in hysterectomy patients.

Detailed description

It is well-known that smoking is very common in the public. The chronic pain after hysterectomy is 20-40%. The open abdominal hysterectomy ratio is 75% of all hysterectomy operations in our country. We know that the reasons of postoperative acute and chronic pain is multifactorial. One of them is smoking which affects the postoperative pain. The best way of measuring the level of cotinine is assesing the urine of the patient. We collect the first urine after induction. In this study, we aimed to investigate the correlation between the levels of urine cotinine and the acute and chronic postoperative pain in hysterectomy patents.

Interventions

DEVICEmeasuring cotinine level

Measuring of the cotinine levels

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

DOUBLE (Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* ASA I-II * Open abdominal hysterectomy patients

Exclusion criteria

* Chronic pain * Chronic pain killer users * Axis I psychiatric disease * Liver disease * Renal disease * Drug allergy

Design outcomes

Primary

Measure	Time frame	Description
Chronic pain: VAS score	Postoperative 3 months	3rd month pain after hysterectomy (VAS score)

Secondary

Measure	Time frame	Description
Acute pain: VAS score	Postoperative 48 hours	Postoperative 24 hrs after hysterectomy (VAS score)

Countries

Turkey (Türkiye)

Contacts

Primary ContactOnur Koyuncu

onurko@yahoo.com+905337744757

Backup ContactSumeyra Gokdemir

sumeyray86@gmail.com+905073992192

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026