Infertility, Female
Conditions
Brief summary
This research study is about the effects of diet and exercise in women undergoing fertility treatment.
Detailed description
This study will randomize women who are undergoing fertility treatment and put them either in an intervention group or standard care. This study should help us learn if diet and exercise changes oocytes gene expression and follicular fluid content.
Interventions
OTHERDiet Intervention - Group 1
They will be provided with a Mediterranean diet plan.
They will be provided with an exercise plan to follow.
Sponsors
Arkansas Children's Hospital Research Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
This research will last up to 12 weeks. The participant will attend two research study visits and will be asked to donate oocytes and follicular fluid to the study team during their oocyte retrieval procedures. They will be randomized (like flipping a coin) to either a standard of care group or an intervention group. If they are in the intervention group, they will also be asked to follow a Mediterranean diet (all meals will be shipped to their home weekly) and exercise at least 3 times a week at a gym or at their house. If they are in the control group, they will follow the normal fertility clinic procedures.
Eligibility
Sex/Gender
FEMALE
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* BMI 25 - 45 kg/m2 * ≥ 21 years of age
Exclusion criteria
* Pre-existing conditions (e.g. sexual transmitted diseases) that will affect the outcomes of the study as determined by the principal investigator * Current use of recreational drugs, tobacco, or alcohol * Food allergies, intolerances or preferences which would interfere with compliance to the meal plan * Contraindications to exercise * Already meeting the physical activity guidelines (150 min moderate activity/week or 75 minutes of vigorous activity/week with resistance exercise on 2 or more days/week).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oocyte gene expression profile | 8-12 weeks | Oocyte gene expression |
| Follicular fluid content | 8-12 weeks | Follicular fluid content |
Countries
United States
Outcome results
None listed