Safe Use of CPAP and PEEP During Induction of General Anesthesia

Safe Use of CPAP During Preoxygenation and PEEP After Apnoea During Induction of General Anesthesia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04271683

Enrollment

Registered

2020-02-17

Start date

2021-10-19

Completion date

2021-12-21

Last updated

2023-05-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anesthesia

Keywords

Positive end-expiratory pressure, Mechanical ventilation, Induction of anesthesia

Brief summary

The study compares the safety of using pressure controlled ventilation with a positive end-expiratory pressure (PEEP) during induction of general anaesthesia immediately after apnoea to a standard method starting ventilation manually without PEEP immediately after apnoea.

Detailed description

Using a continuous positive pressure (CPAP) during preoxygenation, followed by pressure controlled ventilation with PEEP after apnoea during induction of general anesthesia, might offer several benefits but safety issues needs more investigation. This study compares the safety of using pressure controlled with PEEP during induction of general anesthesia immediately after apnoea to a standard method starting ventilation manually without PEEP immediately after apnoea.

Interventions

PROCEDUREPressure controlled ventilation with PEEP

The intervention consists of starting ventilation after apnoea during induction of general anesthesia with pressure controlled ventilation with PEEP instead of manually without PEEP.

PROCEDUREManual ventilation without PEEP

The intervention consists of starting ventilation after apnoea during induction of general anesthesia manually instead of with pressure controlled ventilation with PEEP.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Normal or overweight patients scheduled for day case surgery in general anesthesia. * American Society of Anesthesiologists functional class I-III. * Body Mass Index 18.5-30.

Exclusion criteria

* Increased risk of regurgitation of gastric content. * Symptomatic asthma, COPD or heart failure. * Peripheral oxygen saturation (SpO2) breathing air \<94 % * Anticipated difficult airway. * Beard. * Anatomical features making it difficult to keep a tight seal during maskventilation.

Design outcomes

Primary

Measure	Time frame	Description
Number of breaths until return of CO2.	2 minutes	When starting ventilation after apnea the number of breaths given until the return of CO2 is at least 1.3 kPa at a respiratory frequency of 10 per minute.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026