COPD
Conditions
Brief summary
Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020.
Detailed description
COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversible.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also many others factors such as genetics and cigarette smoking. Cigarettes are harmful and contribute to different extra pulmonary disorders. Although COPD affects lungs some extrapulmonary manifestations are prescribed such as muscle dysfunction, abnormal respiratory muscles and systemic inflammation. Indeed, the systemic inflammation\[6, 8\] is considered as a key process in the pathogenesis of COPD. It involves different cells and molecules; high levels of circulating of white blood cells, increased plasma c-reactive proteins (CRP), interleukin 6 (Il6) have been reported in.those patients.Likewise, systemic inflammation could worsen the comorbidities (cardiovascular, osteoporosis..) and may lead to the exercise limitation.
Interventions
OTHERexercise training
The patients are allocated to PR+ET group or PR Each group receive an exercise training
Sponsors
Faculty of Medicine, Sousse
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
MALE
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* COPD diagnosed by pulmonary function testing * Clinically stable * Abscence of other obstructive diseases * Signed written consent
Exclusion criteria
* Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions * cardiovascular diseases. * Contre-indications to physical therapy * Acute exacerbations a month before the intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Interleukins concentrations | Before the training, 2 months | ELISA assay |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 6Minutes Walk test | Before the training, 2 months | patients performed the test |
Countries
Tunisia
Contacts
Primary ContactAmal Acheche, PhD
Backup ContactYassine Trabelsi, professor
Outcome results
None listed