Evaluation of Adipose Derived Stem Cells Exo.in Treatment of Periodontitis

Effect of Adipose Derived Stem Cells Exosomes as an Adjunctive Therapy to Scaling and Root Planning in the Treatment of Periodontitis: A Human Clinical Trial

Status

UNKNOWN

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04270006

Acronym

exosomes

Enrollment

Registered

2020-02-17

Start date

2020-02-12

Completion date

2021-10-31

Last updated

2020-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Keywords

Periodontitis, SRP, ADSCs, Exosomes, treatment

Brief summary

The adipose stem cells exosomes will be extracted from adipose stem cells isolated autogenously from the patient to be injected locally into the periodontal pockets in order to evaluate their regenerative effect.

Interventions

BIOLOGICALadipose derived stem cells exosomes

they are small extracellular vesicles

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Advanced periodontitis (Stage III or IV) * Healthy patients.

Exclusion criteria

* Smokers, Diabetic, Pregnant ladies, Under corticosteroids or contraceptive treatment,poor oral hygiene.

Design outcomes

Primary

Measure	Time frame	Description
change in gingival inflammation	0, 3 and 6 months	Gingival index (GI)
change in pocket depth	0, 3 and 6 months	Probing depth (PD)
change in attachment level	0, 3 and 6 months	Clinical attachment level (CAL)
change in Bone level	0 and 6 months	Cone beam C.T (CBCT)

Countries

Egypt

Contacts

Primary ContactEbtehal Mohammed, Ph.D

ebtehalmaawad@dent.bsu.edu.eg,01224336896

Backup ContactNoha Saleh, Ph.D

noha.saleh@dentistry.cu.edu.eg

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026