Blood Coagulation Disorder
Conditions
Brief summary
Dexmedetomidine may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of dexmedetomidine. The investigators have therefore performed the present study to measure the effect of dexmedetomidine on the coagulation pathway according to the drug concentration level using a rotational thromboelastometry test.
Interventions
DRUG0 ul of dexmedetomidine
Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 ul) using dexmedetomidine
DRUG0.25 ul of dexmedetomidine
Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.25 ul) using dexmedetomidine
DRUG0.5 ul of dexmedetomidine
Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.5 ul) using dexmedetomidine
DRUG0.75 ul of dexmedetomidine
Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.75 ul) using dexmedetomidine
Sponsors
Seoul National University Bundang Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * Age: 20 to 65 years * Body weight \> 50 kg * Volunteers who provided informed consent
Exclusion criteria
* Hematologic disease * Anticoagulant medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FIBTEM | During the rotational thromboelastometry analysis/ an average of 1 hour | Fibrinolytic pathway values of rotational thromboelastometry analysis/ FIBTEM is not an acronym. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| INTEM | During the rotational thromboelastometry analysis/ an average of 1 hour | Intrinsic pathway values of rotational thromboelastometry analysis/ INTEM is not an acronym. |
| EXTEM | During the rotational thromboelastometry analysis/ an average of 1 hour | Extrinsic pathway values of rotational thromboelastometry analysis/ EXTEM is not an acronym. |
Countries
South Korea
Outcome results
None listed