Periodontal Diseases, Periodontal Inflammation
Conditions
Keywords
periodontitis, gingivitis, matrix metalloproteinases
Brief summary
Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health. Matrix metalloproteinase (MMP)-8 is the major collagenase of periodontal tissue breakdown. The aim of the present study is to analyze active (aMMP-8) levels in gingival crevicular fluid (GCF), saliva and serum in the context of new criteria of gingivitis and stage 3 grade C periodontitis.
Interventions
OTHERBiochemical analysis
aMMP-8 is measured by immunofluorometric assay (IFMA).
Sponsors
Giresun University
Aydin Adnan Menderes University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
25 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* systemically healthy and non-smoker individuals aged 25 to 50 years * having ≥20 teeth present (except third molars) * individuals with periodontally healthy, gingivitis and stage 3 periodontitis diagnoses
Exclusion criteria
* having any systemic disease * smoking * pregnancy or lactation * using antibiotic or any anti-inflammatory drug or any periodontal treatment within the past 6 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oral (GCF and saliva) and serum levels of aMMP-8 in periodontitis and gingivitis | through study completion, an average of 4 months | aMMP-8 levels |
Countries
Turkey (Türkiye)
Outcome results
None listed