Evaluation of Cavernous Sinus Invasion by Pituitary Adenoma Using Deep Learning Based Denoising MR

Prospective MRI Evaluation of Cavernous Sinus Invasion by Pituitary Adenoma Using Deep Learning Based Denoising

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04268251

Enrollment

Registered

2020-02-13

Start date

2020-01-12

Completion date

2022-02-28

Last updated

2024-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cavernous Sinus Invasion by Pituitary Adenoma

Brief summary

Preoperative evaluation of cavernous sinus invasion by pituitary adenoma is critical for performing safe operation and deciding on surgical extent as well as for treatment success. Because of the small size of the pituitary gland and sellar fossa, determining the exact relationship between the pituitary adenoma and cavernous sinus can be challenging. Performing thin slice thickness MRI may be beneficial but is inevitably associated with increased noise level. By applying deep learning based denoising algorithm, diagnosis of cavernous sinus invasion by pituitary adenoma may be improved.

Interventions

DIAGNOSTIC_TESTMRI with deep learning based denoising

1-mm coronal contrast-enhanced T1 weighted image with deep learning based denoising

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients undergoing preoperative brain MR for pituitary adenoma

Exclusion criteria

* Patients who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulates, electronic infusion pumps, etc), because such devices may be displaced or malfunction * Patients who are pregnant or breast feeding; urine pregnancy test will be performed on women of child bearing potential * Poor MRI image quality due to artifacts

Design outcomes

Primary

Measure	Time frame	Description
Cavernous sinus invasion	Within 1 week	Presence or absence of cavernous sinus invasion determined surgically

Secondary

Measure	Time frame	Description
Size of pituitary adenoma (in mm), laterality of pituitary adenoma (unilateral or bilateral) on the MRI	Within 1 week	Size of the tumor (in mm), laterality of the tumor (unilateral or bilateral) on the MRI
Margin of pituitary adenoma (well-delineated, poorly delineated) on the MRI	Within 1 week	Margin of pituitary adenoma (well-delineated, poorly delineated) on the MRI

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026