Type2 Diabetes
Conditions
Brief summary
The study compared the effect of bitter melon intake and moderate exercise on postprandial glucose levels as measured by incremental area under the curve (iAUC) in eight patients with type 2 diabetes.
Detailed description
Background: This study compared the effects of bitter melon intake and moderate-intensity physical activity on postprandial glucose responses in type 2 diabetic patients. Methods: A total of 8 patients with type 2 diabetes were randomly assigned to two sequences (AB, BA) with two treatments (A or B) using a 2 x 2 randomized cross-over design: A) 100 ml of bitter melon juice administered 15 minutes prior to the 75-g oral glucose load; B) 30 minutes walking at moderate-intensity performed 15 minutes after the oral glucose load.
Interventions
DIETARY_SUPPLEMENTBitter melon juice (100 ml)
Fresh bitter melon fruits were purchased from certified local groceries. The seeds of bitter melon were removed, and the juice was obtained from the raw fruit using a blender. Every 140 g of bitter melon fruit produced approximately 100 ml bitter melon juice.
BEHAVIORALExercise
The walking exercise was started 15 minutes after the glucose load. Walking speed was determined to elicit 65% of the maximum heart rate (HRmax) during exercise for each participant. HRmax was estimated using the America College of Cardiology prediction model, HRmax=208 - 0.7 × age. All participants wore a heart rate monitor (Polar, Vantage, XL) around the chest to assess exercise intensity. A rate of perceived exertion was assessed every 2 minutes based on the Borg's scale.
Sponsors
Arizona State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* An age of 20 to 79 years * Physician-diagnosed type 2 diabetes * Medical clearance for physical activity from their healthcare provider
Exclusion criteria
* Pregnant or were receiving insulin treatment * An allergy to bitter melon * Medical conditions that impacted the normal the functioning of the gastrointestinal tract * Contraindications to physical activity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mean glucose | 2-hour postprandial period | mean glucose values |
| incremental area under the curve | 2-hour postprandial period | 2-hour postprandial glucose incremental area under the curve |
Outcome results
None listed