Aortic Stenosis, Glutathione Peroxidase Activity, Transcatheter Aortic Valve Replacement
Conditions
Keywords
glutathione peroxidase, GPx, aortic stenosis, transcatheter aortic valve replacement, TAVR
Brief summary
The aim of this project is to investigate the association of glutathione peroxidase (GPx) and severe aortic stenosis (AS), as well as the impact of transcatheter aortic valve replacement (TAVR) on GPx activity post-procedure. The burden of oxidative stress will be determined by the measurement of GPx, superoxide dismutase (SOD) and lipoprotein A (Lp(a)). We hypothesize GPx activity is reduced in participants with severe AS vs control groups and GPx activity is to increase after TAVR is performed.
Interventions
DIAGNOSTIC_TESTBlood draw to measure GPx activity
Routine blood draw to measure levels of blood markers.
DIAGNOSTIC_TESTBlood draw to measure SOD activity
Routine blood draw to measure levels of blood markers.
DIAGNOSTIC_TESTBlood draw to measure Lp(a) levels
Routine blood draw to measure levels of blood markers.
Sponsors
University of Florida
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age \>18 years * Patients with severe AS including participants with low flow, low gradient severe AS and paradoxical severe AS * Patients meeting criteria for TAVR procedure
Exclusion criteria
* Previous aortic valve replacement (surgical or TAVR) * Participants undergoing chemotherapy * End stage liver disease/cirrhosis (liver produces GSH)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of GPx in blood samples | Baseline up to 6 months | Glutathione peroxidase activity levels measured from whole blood in U/L units in participants with severe aortic stenosis after transcatheter valve replacement compared with the matched population |
Countries
United States
Outcome results
None listed