Clinical and Molecular Aspects of Early Osteoarthritis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04267510

Enrollment

Registered

2020-02-13

Start date

2013-01-01

Completion date

2020-01-01

Last updated

2020-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early Osteoarthritis

Keywords

genetic sequencing

Brief summary

The etiology of osteoarthritis is varied, ranging from multifactorial, environmental to monogenic. In individuals in whom osteoarthritis appears earlier than in the general population, it is called early osteoarthritis. To our knowledge, there are no large-scale genetic studies on people with early osteoarthritis. The investigators therefore sought to study the causes of monogenic osteoarthritis in people suffering from early non-syndromic osteoarthritis. Material and method From 2013 to 2019, experts in constitutional bone disease sent patients with non-syndromic early osteoarthritis for genetic analysis to our center of competence for constitutional bone diseases. The sequencing of a panel of genes was carried out by NGS.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

7 Years to No maximum

Healthy volunteers

Inclusion criteria

\- Patients with early osteoarthritis who have undergone genetic sequencing

Exclusion criteria

\- Patients refusing to participate in research

Design outcomes

Primary

Measure	Time frame	Description
identification of genetic mutation	1 day	sequencing out by NGS
number of genetic mutation	1 day	sequencing out by NGS

Countries

France

Outcome results