Hypertension
Conditions
Keywords
Tai Chi, Hypertension, Randomized Controlled Trial
Brief summary
Several studies investigating Tai Chi for hypertension have been carried out. However, investigators found the results were in high heterogeneity and poor methodological quality. Thus, investigators intend to provide high quality of the effectiveness and safety of Tai Chi for essential hypertension.
Interventions
BEHAVIORALTai Chi
Tai Chi is a traditional Chinese mind-body exercise, which combines deep-breath relaxation and gentle movements in sequence with meditation. Each session of Tai Chi will last 60 minutes, including a 10-minute warm-up, a 40-minute Tai Chi practice and a 10-minute cool-down.
BEHAVIORALWalking
Each session of walking will last 60 minutes, including a 10-minute warm-up, a 40-minute walking and a 10-minutes cool-down.
Sponsors
Chengdu University of Traditional Chinese Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. participants aged between 45 to 80 years; 2. participants diagnosed with mild to moderate hypertension, and meet the diagnostic criteria of mild to moderate hypertension according to 2018 Chinese guidelines for the management of hypertension (140≤SBP≤169 and/or 90≤DBP≤109); 3. participants with or without antihypertensive medication; 4. participants with no regular exercise in the past 3 months; 5. participants willing to comply with the study protocol; 6. participants willing to sign informed consent form.
Exclusion criteria
1. participants diagnosed with secondary hypertension or refractory hypertension; 2. participants with severe medical visceral condition and chronic diseases, such as diabetes, epilepsy, severe depression or anxiety, psychosis; 3. participants with severe bone and joint diseases or motor dysfunction limit ability to participant exercise; 4. participants with severe cognitive decline (Mini-Mental State Examination score, ≤ 20) 5. participants with weak muscle, poor balance or limited vision that would impede full participation in the study; 6. patients participate in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| average 24-h Systolic Blood Pressure (SBP) | change from baseline to 12 weeks after intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change of serum concentrations of Nitric Oxide | baseline, after intervention(12 week) | — |
| change of serum concentrations of endothelin | baseline, after intervention(12 week) | — |
| change of serum concentrations of thromboxane A2 | baseline, after intervention(12 week) | — |
| average SBP and average Diastolic Blood Pressure (DBP) | baseline, after intervention(12 week), after follow-up(24 week) | average SBP and average DBP during the daytime and night-time |
| blood pressure measured at home with an upper arm electronic sphygmomanometer | baseline, after intervention(12 week), after follow-up(24 week) | — |
| Medical Outcomes Study 36-Item Short Form | baseline, after intervention(12 week) | This scale contains eight dimensions (physical function, role physical, bodily pain, general health, vitality, social function, role emotional, mental health) and two summary components (physical and mental), with score from 0 to 100. High scores indicate a better quality of life. |
| change of serum concentrations of vascular endothelial growth factor | baseline, after intervention(12 week) | — |
Countries
China
Contacts
Primary ContactRongjiang Jin, PhD
Backup ContactJuan Li, PhD
Outcome results
None listed