Reduced Radiation Dose and IR-impact on Coronary Calcium Quantification

A Single-center, Multi-scanner, Observational Study to Investigate the Impact of Reduced Radiation Dose and Iterative Reconstruction Algorithms on Coronary Calcium Score in Comparison to the Standard Normal Radiation Dose -Filtered Back Projection Method

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04267094

Enrollment

190

Registered

2020-02-12

Start date

2017-07-01

Completion date

2023-03-07

Last updated

2024-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerotic Plaque

Brief summary

Evaluation of reduced radiation dose iterative reconstruction reconstructions for calcium scoring compared to full dose filtered back projection reconstructions

Interventions

DEVICEIterative reconstruction at reduced radiation dose

Evaluating Agatston coronary calcium score using reduced dose acquisitions reconstructed using iterative reconstruction

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients undergoing routine calcium scoring CT at facilities at the University of Pennsylvania

Exclusion criteria

* Patients found to have no coronary calcium on full dose FBP reconstructions

Design outcomes

Primary

Measure	Time frame	Description
Calcium score	immediate	Calcium score compared to FBP full dose recon

Secondary

Measure	Time frame	Description
Risk stratification	immediate	Cardiovascular risk stratification group of reduced dose IR vs. full dose FBP

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026