Analysis of Driver Gene Mutation in Early Stage Non-small Cell Lung Cancer

Molecular Metastasis in Lymph Nodes is Associated With Survival of Patients With Stage I NSCLC

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04266691

Enrollment

237

Registered

2020-02-12

Start date

2009-01-31

Completion date

2019-06-30

Last updated

2020-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small Cell Lung Cancer

Keywords

Regional Lymph nodes, Molecular metastasis, Driver gene mutation

Brief summary

Analysis of driver gene variation in early stage non-small cell lung cancer

Detailed description

Fluorescence quantitative polymerase chain reaction (PCR) was used to detect the variation of driver gene in regional lymph nodes of early stage non-small cell lung cancer (NSCLC), and to analyze the relationship between the variation and disease recurrence and survival prognosis. evaluate the effect of the variation of driving gene in lymph nodes of early stage NSCLC on prognosis, identify the high-risk factors that promote the recurrence and metastasis of early stage tumor. so as to improve the diagnosis and treatment path of lung cancer, provide important pathological basis for the clinical diagnosis and treatment of early stage non-small cell lung cancer, enable patients to receive more accurate treatment, and improve their survival prognosis.

Interventions

OTHERnonIntervention

nonIntervention

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Female or male, 18 years of age or older 2. Histologically or cytologically proven diagnosis of early stage NSCLC 3. The lesion was completely resected by radical surgery 4. Able to get tumor tissue sample 5. Complete information of clinicopathological , survival, recurrence and metastasis can be obtained through follow-up

Exclusion criteria

1. Combine with other tumor type 2. The investigator judges the situation that may affect the clinical search process and results

Design outcomes

Primary

Measure	Time frame	Description
Driver gene mutation frequency of early stage NSCLC	2019	Observe the driver gene mutation frequency in regional lymph nodes of early stage non-small cell lung cancer
Correlation of Clinicopathological characteristics and driver gene mutation in regional lymph nodes of early stage NSCLC	2019	Analyze the correlation between driver gene mutation and clinicopathological features in regional lymph nodes of early stage NSCLC
Correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC	2019	Observe the correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 13, 2026