ACTH Stability on Whole Blood

Adrenocorticotropic Hormone Stability on Whole Blood

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04266587

Acronym

STABACT

Enrollment

Registered

2020-02-12

Start date

2021-11-18

Completion date

2021-11-18

Last updated

2026-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ACTH

Brief summary

ACTH is a peptide secreted by pituitary gland and plays an important role in regulating cortisol secretion. ACTH is determined in plasma by immunoassays using specific antibodies. Its determination is difficult because of instability in whole blood. Several factors which influence ACTH stability in blood before analysis have been identified: temperature, hemolysis, time to centrifugation and presence of protease inhibitors. Published results on ACTH whole blood stability seem contradictory. The objective of this study is to evaluate the effect of aprotinin in 10 healthy volunteers. ACTH measurements will be performed on cobas e602 (Roche Diagnostics, Mannheim, Germany).

Interventions

BIOLOGICALBlood sampling

blood sampling is done on healthy volunteers

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Adult patient aged 18 to 60,

Exclusion criteria

* Adult with insufficient venous capital for blood collection

Design outcomes

Primary

Measure	Time frame
ACTH concentration in plasma	8 hours

Countries

France

Contacts

PRINCIPAL_INVESTIGATORFrancois FRAISSINET

University Hospital, Rouen

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 11, 2026