Nocturia, Venous Insufficiency of Leg, Fluid Overload
Conditions
Brief summary
With this prospective controlled trial, we hope to obtain more information about the coexistence between venous insufficiency and nocturia. In our opinion, venous insufficiency (CEAP 2-3a) leads to an increase in fluid accumulation in the lower limbs due to moving around all day. When laying down during nighttime, this fluid is reabsorbed into the systimic fluid pool, leading to an increase in diuresis and thus an increase in nocturnal voiding. Aim of this study is observe difference in nocturnal frequency and urine production before and after surgical treatment of venous insufficiency.
Interventions
OTHERQuestionnaires
ICIQ FLUTS (women) or MLUTS (mannen) CIVIQ 2 PSQI
DIAGNOSTIC_TESTFrequency Volume Chart
Collect a frequency volume chart for 3 days: measure the amount of voids and volume urinated.
DIAGNOSTIC_TESTCollect urine during 1 day
Volunteers are asked to collected their urine during the last day of the frequency volume chart. Volunteers get 2 jars: One for collection during the day, and 1 for overnight collection of urine. Osmolality and sodium of urine is tested
DIAGNOSTIC_TESTBlood sample
Blood collection to measure plasma sodium and osmolality.
DIAGNOSTIC_TESTMeasurement of the circumference of the lower legs
Circumference of the lower legs wil be measured twice: * After awakening, when still laying dowing in bed * Before goin to sleep Circumference should be measured 2 cm above the medial malleolus
Sponsors
University Hospital, Ghent
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* CEAP 2 till 4A
Exclusion criteria
* BMI higher than 30 * Previous surgery due to venous insufficiency at the lower limbs * Cronic edema (Cronic heart failure, liver cirrosis, nefrotic syndrome) * Pregnant patient * Patients on the following medication: Calcium-antagonists, lithium, NSAID's or corticosteroids, glitazones, insuline, diuretics, sartans, ACE-inhibitors, desmopressine,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of micturition frequency | 2 months after surgery | Change of the micturition frequency with 1 void |
Secondary
| Measure | Time frame |
|---|---|
| Change in nocturnal diuresis | 2 months after surgery |
Countries
Belgium
Outcome results
None listed