Skin Condition
Conditions
Brief summary
To assess collagen and zhuyin drink on skin & body condition improvement
Interventions
DIETARY_SUPPLEMENTPlacebo drink
consume 1 bottle (50 mL) per day for 28 days
DIETARY_SUPPLEMENTCollagen Cubilose Drink
consume 1 bottle (50 mL) per day for 28 days
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Masking description
Single
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults aged above 20 years old
Exclusion criteria
* Subject who is not willing to participate in this study. * Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history). * Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. * Female who is pregnant or nursing or planning to become pregnant during the course of the study. * Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks. * Vegetarian * Subjects who have large spots (area \>3 square centimeter) or abnormal acne.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of metallopeptidase inhibitor 1 | Change from Baseline skin brightness at 4 weeks | Venous blood was sampled to measure concentrations of metallopeptidase inhibitor 1. |
| The change of interleukin-6 | Change from Baseline skin brightness at 4 weeks | Venous blood was sampled to measure concentrations of interleukin-6. |
| The change of interleukin-8 | Change from Baseline skin brightness at 4 weeks | Venous blood was sampled to measure concentrations of interleukin-8. |
| The change of Tumor necrosis factor | Change from Baseline skin brightness at 4 weeks | Venous blood was sampled to measure concentrations of Tumor necrosis factor. |
| The change of Matrix metalloproteinase-1 | Change from Baseline skin brightness at 4 weeks | Venous blood was sampled to measure concentrations of Matrix metalloproteinase-1 . |
| The change of skin moisture | Change from Baseline skin moisture at 4 weeks | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 |
| The change of skin wrinkles | Change from Baseline skin wrinkles at 4 weeks | VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units |
| The change of skin collagen density | Change from Baseline skin collagen density at 4 weeks | DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units:Intensity score |
| The change of TEWL | Change from Baseline TEWL at 4 weeks | Tewameter® TM 300 was utilized to measure TEWL. Units: g/h/m2 |
| The change of skin brightness | Change from Baseline skin brightness at 4 weeks | Glossymeter GL 200 was utilized to measure skin brightness. Units: arbitrary units |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin pores | Change from Baseline skin pores at 4 weeks | VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units |
| The change of skin spots | Change from Baseline skin spots at 4 weeks | VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units |
| The change of red areas | Change from Baseline red areas at 4 weeks | VISIA Complexion Analysis System was utilized to measure red areas. Units: arbitrary units |
| The change of skin texture | Change from Baseline skin texture at 4 weeks | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units |
Countries
Taiwan
Outcome results
None listed