Coagulation Disorder
Conditions
Brief summary
Our study included both in- and outpatients suffering from liver cirrhosis attending the out- and inpatient care of the department of hepatology. Demographic and biochemical data as well as medical history including cause of liver cirrhosis, end stage kidney failure and medication with anticoagulants were recorded. To assess the hemostatic profile, platelet function was analyzed by multiple electrode aggregometry (MEA) using Multiplate (ADP-, ASPI- and TRAP-test) and thrombelastometry using ROTEM (EXTEM, INTEM, FIBTEM).
Interventions
OTHERAssessment of hemostatic profile
To assess the hemostatic profile, platelet function was analyzed by multiple electrode aggregometry (MEA) using Multiplate (ADP-, ASPI- and TRAP-test) and thrombelastometry using ROTEM (EXTEM, INTEM, FIBTEM)
Sponsors
Goethe University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* liver cirrhosis * age of ≥ 18 years * platelet count of at least 70 / nl
Exclusion criteria
* transfusion of platelet concentrate three weeks prior to inclusion * pregnancy * age \< 18 years * missing informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Aggregation of platelets | Venous blood was collected via a cannula inserted into a cubital vein. Platelet function was measured by MEA using the Multiplate analyzer 15min after blood draw and after activation with commercially available standard reagents | AUC of impedance aggregometry using multiple electrode aggregometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Viscoelastic measurements | Venous blood was collected via a cannula inserted into a cubital vein. Thrombelastometric assays were performed 15min after blood draw. | Viscoelastic measurements of ROTEM assays (EXTEM, INTEM, FIBTEM) |
Countries
Germany
Outcome results
None listed