Epilepsy, Temporal Lobe
Conditions
Keywords
Epilepsy, surgery, temporal lobe
Brief summary
This study will give important information about long term consequences of temporal lobe epilepsy surgery on cognition (memory, language, concentration etc), psychiatric function and quality of life.
Detailed description
All patients in Norway who have undergone temporal lobe epilepsy surgery ten years ago or more, will be invited to participate. Two groups will be compared: patients who are younger than 50 years of age vs patients who are older than 50 years of age. The aim of the study is to improve preoperative information to future epilepsy surgery patients, to aid medical personnel (doctors, psychologists) in the selection of patients for surgery, and to improve knowledge of need for long term follow-up and rehabilitation.
Interventions
Neuropsychological follow-up examination, including questionaires
Sponsors
Oslo University Hospital
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Prior temporal lobe epilepsy surgery (10 years ago or more)
Exclusion criteria
* Intelligence quotient (IQ) less than 70 * Other main language than Norwegian
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in each study group on neuropsychological tests of memory from baseline (preoperative) to current evaluation | During single data collection session, aproximately 2 hours | Memory will be measured by Rey Auditory Verbal Learning Test, results reported as raw scores from 1-worst to 15-best; and Diagnosticum für Cerebralschädugung-Revised - DCS-R, results reported as raw scores from 1-worst to 15-best. All results will be converted to T-scores with average 50, standard deviation 10. |
| Change in each study group on neuropsychological tests of language from baseline (preoperative) to current evaluation | During single data collection session, aproximately 2 hours | Language will be measured by the subtest Similarities from Wechsler Adult Intelligence Scale - WAIS-III, results reported as raw scores from 1-worst to 33-best; Boston Naming Test-results reported as raw scores from 1-worst to 60-best; Letter Fluency from Delis Kaplan Executive Function Scale-D-KEFS, raw scores from 1-worst and up. All results will be converted to T-scores. |
| Change in each study group on neuropsychological tests of visuospatial abilities from baseline (preoperative) to current evaluation | During single data collection session, aproximately 2 hours | Visuospatial abilities will be measured by the subtest Block Design from WAIS-III, raw scores from 1-worst to 68-best. Results will be converted to T-scores. |
| Change in each study group on neuropsychological tests of executive function from baseline (preoperative) to current evaluation | During single data collection session, aproximately 2 hours | Executive function will be measured by the subtest Digit Span from WAIS-III, raw scores from 1-worst, to 30-best; Trails A and B from Halstead test battery, raw scores from 1-worst and up. All results will be converted to T-scores. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Score on depression questionaire | During single data collection session, aproximately 2 hours | Beck Depression Inventory (raw scores divided in 4 categories: 0-13 minimal depression, 14-19 mild depression, 20-28 moderate depression and 29-63 serious depression). |
| Score on anxiety questionaire | During single data collection session, aproximately 2 hours | Beck Anxiety Inventory (raw scores divided in 4 categories: 0-7 minimal anxiety, 8-15 mild anxiety, 16-25 moderate anxiety and 26-63 serious anxiety). |
| Score on quality of life inventory | During single data collection session, aproximately 2 hours | Quality of Life in Epilepsy - QUOLIE 89 - results will be reported as overall score ranging from 26-worst, to 95-best, and converted to T-score with average 50, standard deviation 10) |
Countries
Norway
Outcome results
None listed