Obesity
Conditions
Brief summary
The study was aimed at investigating the relationship between skeletal muscle mass and interventricular septum thickness in overweight and obese subjects (BMI≥25)
Detailed description
Subjects were enrolled at the first examination whether they were not taking any medication, including oral contraceptives or drugs for osteoporosis, and free of significant medical illnesses, except obesity. Exclusion criteria were history of endocrinological diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), chronic inflammatory diseases, stable known hypertension, angina pectoris, stroke, transient ischemic attack, heart infarction, congenital heart disease, malignancies, chronic inflammatory diseases, renal and liver failure, angina pectoris, myocardial infarction, heart failure, congenital heart diseases, minor and major stroke, and inherited thrombocytopenias and other major malignancies. Subjects were examined by means of the medical history, hormonal, metabolic and routine hematochemical parameters. The investigators provided for a clinical baseline evaluation that included extemporaneous ambulatory blood pressure (BP), echocardiography, bioimpedance and a physical assessment of body weight, Body Mass Index (BMI) and Waist Circumference (WC) as anthropometric parameters.
Interventions
OTHERObservational
Observational
Sponsors
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Overweight or obesity (BMI\> 25 Kg/m2)
Exclusion criteria
* Any kind of drug * Hypertension * Endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), * Chronic inflammatory diseases * Renal failure * Liver failure * Angina pectoris * Myocardial infarction and heart failure * Genetic heart diseases * Thrombocytopenias
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| interventricular septum thickness | Baseline | interventricular septum thickness (mm) |
| skeletal muscle mass | Baseline | skeletal muscle mass (kg) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| eGFR (estimated glomerular filtration rate) | Baseline | eGFR (ml/min/1.73 mq) |
| Creatinin | Baseline | Creatinin (mg/dl) concentration in serum |
| Total cholesterol | Baseline | Total cholesterol (mg/dL) concentrations in serum |
| Thyroid hormones (FT3, FT4) | Baseline | FT3 (pg/mL), FT4 (pg/mL) concentration in serum |
| HDL cholesterol | Baseline | HDL cholesterol (mg/dL) concentrations in serum |
| Vitamin D | Baseline | Vitamin D (ng/mL) concentration in serum |
| TSH | Baseline | TSH (mU/L) concentration in serum |
| BMI | Baseline | BMI (kg/m\^2) |
| Height | Baseline | Height in meters |
| Weight | Baseline | Weight in kilograms |
| LDL cholesterol | Baseline | LDL cholesterol (mg/dL) concentrations in serum |
| Insulin | Baseline | Insulin (mIU/L) concentration in serum |
Countries
Italy
Outcome results
None listed