Gestational Diabetes
Conditions
Brief summary
Breastfeeding has been associated with decreased obesity. However, this relationship is not as clear in children who have been exposed to GDM and the mechanisms involved are little known. The overall objective of the project is to study the mechanisms of breastfeeding on the growth of children in women who have had a GDM. More specifically, the project want to compare the macronutrient and hormone composition of breast milk of women with and without GDM. Investigators also want to associate the levels of hormones related to satiety and energy metabolism (i.e. endocannabinoids, ghrelin, leptin) in the human milk of women with or without DG and the growth of the child. A total of 60 women (30 with GDM and 30 without GDM) will collect breastmilk at 2 months postpartum.
Detailed description
Other data collected: Waist circumference, DXA, Fasted blood sample, Oral glucose tolerance test, Breastfeeding habits, Food habits, Baby's height et weight.
Interventions
None listed
Sponsors
Laval University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Breastfeeding women
Exclusion criteria
* Type 1 or type 2 diabetes * Preterm birth * History of bariatric surgery * Multiple births
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study the mechanisms linked to the effect of breastfeeding on the growth of children in women who have had GDM. | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Compare macronutrient and hormone composition of breast milk of women with and without GDM. | 6 months |
| Associate level of hormones related to satiety and energy metabolism (i.e. endocannabinoids, ghrelin, leptin) in the human milk of women with or without GDM and the growth of the child. | 6 months |
Countries
Canada
Outcome results
None listed