Alcohol; Harmful Use
Conditions
Brief summary
This study evaluates the efficacy as well as psychological and neurobiological mechanisms of mobile-delivered alcohol attentional bias modification among heavy drinking adults.
Detailed description
By testing the efficacy and neurobiological mechanisms of behavior change (MOBC) following attentional bias modification among heavy drinking adults, the proposed study has the potential to unify dual process models and neurobiological models of addiction. The cognitive retraining will be delivered via mobile electronic devices to ensure the cost-effectiveness of these procedures, to allow a large amount of retraining to be delivered in an ecologically valid manner, and to facilitate broad dissemination of such procedures if found to be efficacious. Using an intensive longitudinal experimental design, subjects will be randomly assigned into one of 2 groups (attentional bias modification vs. attentional bias control). Ecological momentary assessment (EMA) data will be used to assess changes in cognitive and behavioral measures in situ, and functional magnetic resonance imaging (fMRI) scans before and after cognitive retraining will be used to examine neural changes in specific regions of interest (ROI).
Interventions
BEHAVIORALAttentional Bias Modification
Mobile-Delivered Cognitive Retraining Intervention
Sponsors
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
University of New Mexico
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
Participants are not informed about the nature of the mobile-delivered intervention or their assignment to the intervention or control condition.
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Alcohol Use Disorders Identification Test greater than or equal to 8 * right-handed
Exclusion criteria
* history of treatment for or diagnosis of alcohol use disorder/substance use disorder * history of brain injury * for females, currently pregnant * any MRI safety contraindication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Alcohol Use Frequency | 4 weeks | Number of days of alcohol use during the 4-week ecological momentary assessment period |
| Alcohol Use Quantity | 4 weeks | Number of standard drinks per day during the 4-week ecological momentary assessment period |
| Negative Alcohol-Related Consequences | 4 weeks | Number negative consequences experienced 4-week ecological momentary assessment period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Attentional Bias to Alcohol | 4 weeks | Measured with the Alcohol Dot Probe Task |
| Alcohol Cue-Induced Neural Reward Circuit Activation | 4 weeks | Regions of interest include ventral tegmental area, dorsal and ventral striatum |
Countries
United States
Outcome results
None listed