Exercise Performance
Conditions
Brief summary
We evaluated here the effects of 6-week intervention with herbal supplement on exercise performance outcomes and serum biomarkers of antioxidant status. In addition, we also assessed the long-term effects (6-month) of the intervention in elderly adults.
Detailed description
Experimental protocol * Double-blind, randomized, placebo-controlled cross-over trial * 6-week intervention trial (with additiional follow-up arm after 6 months) * Experimental intervention (PhytoDyNAmic) = 6 capsules per day * Placebo (inulin) = 1 g per day b.i.d. * Administration = 3 capsules with breakfast and 3 capsules with dinner * Wash-out period = 2 weeks * No changes in physical activity patterns and diet during the study Outcomes assessed at baseline and at each follow-up: * Exercise performance during incremental running-to-exhaustion test * Serum biomarkers of antioxidant status * Total antioxidant capacity (TAC) * Superoxide dismutase (SOD) * Telomerase activity Early termination criteria \- Serious subjective side effects of an intervention (e.g. nausea, vomiting, bloating)
Interventions
DIETARY_SUPPLEMENTPhytoDyNAmic
PhytoDyNAmic (6 capsules per day)
DIETARY_SUPPLEMENTInulin
Inulin (6 capsules per day)
Sponsors
University of Novi Sad, Faculty of Sport and Physical Education
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 18 years * Body mass index 19 - 25 kg/m2 * Free of major chronic diseases or acute disorders
Exclusion criteria
* Use of dietary supplements within 4 weeks before study commences * Unwillingness to return for follow-up analysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in time to exhaustion | Baseline vs. 6 weeks post-intervention | Baseline vs. 6 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum superoxide dismutase | Baseline vs. 6 weeks post-intervention | Baseline vs. 6 weeks |
| Change in serum total antioxidant capacity | Baseline vs. 6 weeks post-intervention | Baseline vs. 6 weeks |
| Change in serum telomerase activity | Baseline vs. 6 weeks post-intervention | Baseline vs. 6 weeks |
Countries
Serbia
Outcome results
None listed