Remineralization of Caries Affected Dentin

Effect of Pulpine and Combination of Pulpine With Polyamidoamine Dendrimer on Remineralization of Carious Affected Human Dentin

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04262076

Enrollment

Registered

2020-02-10

Start date

2018-06-01

Completion date

2020-01-01

Last updated

2020-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep Caries

Brief summary

Remineralization of carious affected dentin

Detailed description

Remineralization of Carious affected dentin by using Pulpine alone and combination of Pulpine with Polyamidoamine Dendrimer.

Interventions

OTHERPulpine with Polyamidoamine Dendrimer

Removal of infected dentin in class I Cavities followed by application of Polyamidoamine Denrimer on caries affected Dentin that is washed out of the cavity after 30 secs then finally place Pulpine .

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Intervention model description

split mouth design

Eligibility

Sex/Gender

ALL

Age

18 Years to 25 Years

Healthy volunteers

Yes

Inclusion criteria

* Presence of at least one class one carious posterior teeth in both left and right side. * Absence of spontaneous pain, Mobility and tenderness on percussion. * Radiographically, the preoperative inclusion criteria are, no internal or external resorption and no widening of the periodontal membrane space.

Exclusion criteria

* Patients with poor oral Hygiene. * Evidence of Rampant Caries. * Teeth with periodontal involvement. * Poor general health condition.

Design outcomes

Primary

Measure	Time frame	Description
Remineralization & increase dentin density that is measured by using Vista Scan Radiography.	6 months	Vista scan Radiography used to measure pixel grey value after 6 months.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026