Liver Transplantation
Conditions
Brief summary
This is a retrospective cohort study. Patients who underwent liver transplantation from January 1, 2016 to December 31, 2019 were admitted to the study and divided into two groups. Operating room extubation group: early extubation in the operating room immediately following liver transplantation. Intensive care unit (ICU) extubation group: delay extubation in the ICU following liver transplantation. The primary objectives were to compare the incidence of composite outcome between the two groups. secondary objectives were to compare outcomes such as length of stay, hospital length of stay, and total cost between the two groups.
Detailed description
Patients who underwent liver transplantation from January 1, 2016 to December 31, 2019 were admitted to the study. Inclusion criteria: (1) adult patients (age ≥ 18 years), (2) undergoing liver transplantation. Exclusion criteria were the following: (1) re-transplantation; (2) multi-visceral transplantation; (3) intraoperative death; (4) severe encephalopathy (West Haven criteria III or IV); (5) those who had preoperative mechanical ventilation; (6) incomplete clinical data. The primary objectives was a composite of 30-day all-cause mortality, in-hospital AKI, or in-hospital moderate to severe pulmonary complications. Complications were defined and graded as mild, moderate, or severe as described by European Perioperative Clinical Outcome definitions and were included if they occurred in hospital after surgery. The secondary objectives included in-hospital moderate to severe infectious complications, unplanned reintubation rates, ICU and postoperative hospital lengths of stay, and total hospital cost.
Interventions
PROCEDUREextubation in the operating room
Patients who underwent liver transplantation early extubation in the operating room immediately following liver transplantation
PROCEDUREextubation in the ICU
Patients who underwent liver transplantation extubation in the ICU following liver transplantation
Sponsors
West China Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (age ≥ 18 years) * Undergoing liver transplantation
Exclusion criteria
* Re-transplantation * Multi-organ transplants * Intra-operative deaths * severe encephalopathy (West Haven criteria III or IV) * patients who had preoperative mechanical ventilation or fulminant hepatic failure * Incomplete clinical data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of a composite of 30-day all-cause mortality, AKI and moderate to severe pulmonary complications. | through study completion, an average of 1 year | Complications were defined and graded as mild, moderate, or severe as described by European Perioperative Clinical Outcome definitions and were included if they occurred in hospital after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of moderate to severe infectious complications | 30 days | Complications were defined and graded as mild, moderate, or severe as described by European Perioperative Clinical Outcome definitions and were included if they occurred in hospital after surgery |
| The incidence of re-intubation. | 30 days | Reintubation was defined as intubation after extubation of a patient who had been initially tracheal intubated under general anaesthesia |
| The length of hospital stay | through study completion, an average of 1 year | Length of hospital stay is the duration of a single episode of hospitalization |
| The length of ICU stay | through study completion, an average of 1 year | Length of ICU stay is the duration of a single episode of ICU hospitalization |
| The total hospital cost | 30 days | The total hospital cost |
Countries
China
Outcome results
None listed