Thalassemia Major
Conditions
Brief summary
The effect of N-acetylcysteine as antioxidant and its effect on pretransfusion hemoglobin and iron overload in patients with thalassemia were compared to patients who didn't receive n-acetylcysteine after 3 months of study duration
Detailed description
N-acetylcysteine( NAC) is a widely used mucolytic drug and several studies had reported its efficacy as anti oxidant. Patients with thalassemia major are at great risk for oxidative stress due to excess of b-globin chains and iron overload. In this study the investigators compared the effect of NAC on oxidative status , pretransfusion hemoglobin levels and iron overload in thalassemia patients before and after treatment with NAC for 3 months and with that of patients who served as controls.
Interventions
DRUGN-acetyl cysteine
Mucolytic and antioxidant drug
Sponsors
Beni-Suef University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Two groups are followed up for study parameters for 3 months one group is the intervention group and the other is the control group
Eligibility
Sex/Gender
ALL
Age
3 Years to 14 Years
Healthy volunteers
No
Inclusion criteria
* Thalassemia major children on regular blood transfusion and iron chelation therapy
Exclusion criteria
* Renal or hepatic impairments * Complicated thalassemia major * Non adherence to therapy or follow up visits * Change in the iron chelation dose within 3 months before enrollment or during study period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxidative stress index (pg/mmol) | 3 months | Oxidative stress index is calculated as the ratio of total oxidative status (pg/dl) to total anti oxidative capacity (mmol/dl) |
| Serum ferritin level ( mg/dl) | 3 months | — |
Countries
Egypt
Outcome results
None listed