Effect of Retrograde Autologous Blood Priming on Pulmonary Mechanics in Pediatric Cardiac Surgery

Effect of Retrograde Autologous Blood Priming of Cardiopulmonary Bypass on Hemodynamic Parameters and Pulmonary Mechanics in Pediatric Cardiac Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04260204

Acronym

RAPCPB

Enrollment

124

Registered

2020-02-07

Start date

2015-01-02

Completion date

2020-01-25

Last updated

2020-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital Heart Disease

Keywords

retrograde autologous priming pulmonary mechanics

Brief summary

The present study hypothesized that beyond its hemodynamic affects,retrograde autologus blood priming of cardiopulmonary bypass (RAP) has a positive impact on hemodynamics and pulmonary mechanics subjected to cardiac surgery.

Detailed description

This prospective randomized study analyzed the clinical records of 124 children subjected to cardiac surgery for congenital heart diseases with left to right shunt. They comprised 64 patients with RAP and 60 patients conventional cardiopulmonary bypass priming. The preoperative, intraoperative and postoperative data of the studied patients were reported.

Interventions

PROCEDUREPediatric cardiac surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Masking description

double-blind masking

Intervention model description

Patients were included in the study if they had left to right shunt due to volume or pressure overload

Eligibility

Sex/Gender

ALL

Age

12 Months to 5 Years

Healthy volunteers

Inclusion criteria

* children complained of congenital heart disease with left to right shunt pressure or volume load

Exclusion criteria

* cyanotic heart disease

Design outcomes

Primary

Measure	Time frame	Description
Comparison of postoperative peak air way pressure between the studied groups	1 hour after surgery	peak air way pressure (Paw) in cmH2O
Comparison of postoperative air way resistance between the studied groups	1 hour after surgery	air way resistance (Raw) in cmH2O/L/sec.
Comparison of postoperative Plateau pressure between the studied groups	1 hour after surgery	Plateau pressure in cm H2O
Comparison of postoperative Lung compliance between the studied groups	1 hour after surgery	Lung compliance in L/cm H2O
Comparison of postoperative Tidal volume between the studied groups	1 hour after surgery	Tidal volume in ml

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026