Lymph Node Yield in Colon Cancer Resection Specimens

Macroscopic Evaluation of Colon Cancer Resection Specimens to Predict Metastatic Lymph Node Yield

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04260139

Enrollment

Registered

2020-02-07

Start date

2019-09-01

Completion date

2020-10-01

Last updated

2020-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Cancer, Lymph Node Metastases

Keywords

ileocolic pedicle, colon cancer, Staging

Brief summary

In this study, we aimed to develop a predictive model of lymph node yield in a series of colon cancer resection specimens with detailed anatomic and surgical technique data.

Detailed description

Lymph node yield in colon resection specimens has been associated with the accuracy of staging and cancer outcomes. It has been proposed that the more central the mesenteric vascular ligation, the greater the nodal yield. However, the optimal number of harvested nodes is still a matter of debate. We prospectively evaluated the relation between specimen properties such as lenght, area, tumor location and pedicle length to the number of harvested nodes and rate of node positivity.

Interventions

PROCEDURECalculation of metric variables on the colectomy specimens.

Calculation of metric variables on the colectomy specimens including Lengths as mm 1. Proximal colon, 2. Ileum in cases with right hemicolectomy only, 3. Proximal border, 4. Tumor, 5. Distal border, 6. Total specimen, 7. Vascular pedicle, the longitudinal distance between the nearest bowel wall and the end of ligated major vascular pedicle depending on the tumor's localization, 2. Colonic mesenteric area as mm2.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

The surgical patients with a histologic diagnosis of colonic neoplasm, Colectomy of any type, including the right hemicolectomy, the left hemicolectomy, the sigmoid resection, segmental colon resection

Exclusion criteria

* rectal or rectosigmoid cancer colectomy beyond the inclusion criteria for colectomies patients younger than 18 previous colon resection emergency colon resection familial adenomatous polyposis or ulcerative colitis

Design outcomes

Primary

Measure	Time frame	Description
Lymph Node Yield in Colon Cancer Resection Specimens	September 2019- November 2020	Count of lymph node

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026