Septic Shock
Conditions
Keywords
Cerebrovascular Autoregulation, Septic Shock, Cytokine
Brief summary
The trial investigates the effect of cytokine elimination in patients with septic schock and acute renal failure with need for renal replacement therapy on the integrity of cerebrovascular autoregulation. Patients with inclusion criteria were randomly assign in either use of CytoSorb filter integrated in renal replacement therapy versus non additional filter an renal replacement therapy alone. Cerebrovascular autoregulation will be measured with transcranial Doppler ultrasound and correlation with arterial blood pressure.
Interventions
DEVICECytokine absorption
Use of CytoSorb absorber
Sponsors
Johannes Gutenberg University Mainz
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* septic shock * acute renal failure with need for renal replacement therapy
Exclusion criteria
* pregnancy * nursing * impossibility to do transcranial Doppler ultrasound
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in the index of cerebrovascular autoregulation (Mx) between both groups | days 1 to 4 after diagnosis of septic shock | Integrity of the cerebrovascular autoregulation will be measured using the index of cerebrovascular autoregulation Mx (moving correlation index). Outcome is the difference of the mean Mx between both groups and, therefore, the difference of integrity of the cerbrovascular autoregulation. A difference of 0.2 in Mx was set as clinically relevant. |
Countries
Germany
Outcome results
None listed