Esophageal Atresia
Conditions
Brief summary
Children with esophageal atresia who undergo surgical repair are at risk for anastomotic stricture following surgery. Esophageal stricture can be treated with serial endoscopic dilation but may ultimately need surgical resection if the stricture proves refractory to therapy. Several risk factors have been reported for development of recalcitrant stricture, but to date, no studies have specifically examined the relationship between anastomotic thickness and echotexture at time of initial postoperative endoscopy and treatment outcomes. Other risk factors that have been implicated in the development of recalcitrant stricture include gastroesophageal reflux disease, anastomotic leak, long-gap esophageal atresia, and gestational age. Moreover, it is poorly understood how esophageal layers alter and progress with repeated therapeutic dilation. The investigator hypothesize that the initial thickness and echotexture will help determine therapeutic outcome. It will also help us understand the progression of esophageal echotexture following therapeutic dilation.
Interventions
DEVICEPediatric endoscopic ultrasound
endoscopic ultrasound at the esophageal stricture site to assess echo texture and esophageal layers
Sponsors
Boston Children's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Months to 21 Years
Healthy volunteers
No
Inclusion criteria
\- Patients ages 0-21 years old at time of evaluation with a suspected diagnosis of esophageal stricture secondary to esophageal atresia (with or without Tracheoesophageal fistula) post surgical repair
Exclusion criteria
* Patients with pre-diagnosis of eosinophilic esophagitis * Patients with pre-diagnosis of congenital esophageal stricture * Patients diagnosed with esophageal stricture secondary to caustic ingestion * Patient is diagnosed with an esophageal perforation at time of endoscopy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predict post surgical primary repair outcome in patients with esophageal atresia using endoscopic ultrasound | 2 years | Patients with esophageal atresia following surgical repair will undergo an endoscopic ultrasound procedure to measure esophageal layer thickness and to describe esophageal echo-texture characteristics at the anastomotic site |
Contacts
Primary Contactosama baghdadi, MBBS
Outcome results
None listed