Anesthesia and Cancer Study: Colon Cancer

The Influence of Type of Anesthesia on Mortality and Cancer Recurrence After Colon Cancer Surgery: Multi-center Prospective Randomized Controlled Study

Status

Active, not recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04259398

Enrollment

797

Registered

2020-02-06

Start date

2020-02-18

Completion date

2028-05-03

Last updated

2023-11-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Cancer of Colon

Keywords

anesthesia, propofol, cancer, inhalational anesthetics

Brief summary

This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.

Detailed description

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.

Interventions

DRUGPropofol

propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia

DRUGSevoflurane

sevoflurane is administered for induction and maintenance of anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to 80 Years

Healthy volunteers

Inclusion criteria

* adults undergoing surgery to remove colon cancer

Exclusion criteria

* pregnancy * colon cancer with invasion to perineum * palliative surgery * history of diagnosis or surgery for other cancer * emergent surgery * ASA PS classification 4 and 5 * refusion to participate in the study * allergy to anesthetics

Design outcomes

Primary

Measure	Time frame	Description
five year survival	five years survival	survival rate regardless of recurrence

Secondary

Measure	Time frame	Description
five year recurrence free survival	five years after surgery	survival rate without recurrence
1 year recurrence free survival	1 year after surgery	survival rate without recurrence
3 year recurrence free survival	3 years after surgery	survival rate without recurrence
1 year survival	1 year after surgery	survival regardless of recurrence
3 year survival	3 years after surgery	survival regardless of recurrence

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026