Advanced Cancer
Conditions
Brief summary
Assessment of efficacy of primary cyto-reductive surgery in patients with advanced primary epithelial ovarian cancer in Comparison to patients receiving neo-adjuvant chemotherapy (NAC) followed by surgery in complete excision of the tumor reaching R0 without significant morbidity.
Interventions
PROCEDURE1ry cyto-reductive surgery
1ry surgery then chemotherapy
COMBINATION_PRODUCTNeoadjuvant chemotherapy followed by surgery
chemotherapy then surgery
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Female patients diagnosed with epithelial ovarian cancer (By histopathology) Age ≥ 18 years old Advanced defined as (stage 2D or more ) by surgical staging. Performance status (PS) according to Eastern Cooperative Oncology Group (ECOG) ≤ 2 Chemotherapy naïve Informed consent
Exclusion criteria
Patients previously received chemotherapy or radiotherapy to any part of the abdomen or pelvis. Patients with uncontrolled infection. Patients with active bleeding or conditions associated with high risk of bleeding. contraindications for surgery contraindications To chemotherapy - bevacizumab
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of patient where complete resection of the tumor can be achieved | 3 month postoperative | complete resection of the tumor |
Countries
Egypt
Contacts
Primary ContactAli H Ali Sayed, M.Sc
Outcome results
None listed