Optic Neuritis
Conditions
Keywords
optic neuritis, clinical Characteristics, epidemiology
Brief summary
This will be a hospital-based retrospective multi-center study on epidemiologic and clinical characteristics of optic neuritis among Chinese. The investigation will cover about 29 provinces or municipalities all around China.
Detailed description
This national investigation will be conducted to describe the epidemiology and clinical characteristics of optic neuritis in China. All the patients will be divided into 3 groups according to the serum demyelinating antibodies (Aquaporin-4 antibody seropositive group, Myelin oligodendrocyte glycoprotein antibody seropositive group and double seronegative group). The investigator will analyze the differences among the three groups. Primary outcomes: * To dig out the different visual acuity (VA, LogMAR) prognosis among the three groups; * To calculate the annual relapse rate (ARR) differences among the three groups (relapse times in all the follow-up time in each group/ follow-up time (years) in all in each group). Secondary outcomes: * Other epidemiological and clinical characteristics of optic neuritis patients will be analyzed among the three groups; * Orbital or Brain MRI is required in this study, which could avoid the misdiagnosis. We will collect and analyze these MRI data too (including the optic nerve lesions in T2 weight images and T1 enhanced MRI); * Results of optical coherence tomography (OCT) (including peripapillary retinal nerve fiber layer, macular thickness ,and ganglion cell and inner plexiform layer complex) at different time point are also needed in this study. However, OCT is not necessarily required; * Visual fields at different time points are also encouraged to provide if they are available.
Interventions
OTHERobservation
different serum antibodies status
Sponsors
Peking University Health Science Center
Chinese PLA General Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Clinical diagnosis of optic neuritis 2. The patients' medical records were complete
Exclusion criteria
1. Patients with unclear diagnosis of optic neuritis 2. Incomplete medical records
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Acuity | At least 1 year from the attack to the final visit | Last visual acuity records in the hospital |
| Annual Relapse Rate | At least 1 year from the attack to the final visit | Calculated annual relapse rate of different subgroups in the cohort |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Epidemiologic characteristics of optic neuritis | At least 1 year from the attack to the final visit | Gender, age of first attack, location |
| Clinical characteristics of optic neuritis | At least 1 year from the attack to the final visit | Visual acuity at nadir, pain, optic disc edema |
| Optical Coherence Tomography | At least 1 year from the attack to the final visit | RNFL, macular thickness and GCIPL at different time points |
| Orbit or Brain MRI at the attack | At least 1 year from the attack to the final visit | Lesions of the optic nerve |
Countries
China
Contacts
Primary ContactMo Yang, Ph.D
Backup ContactMengying Lai, M.D
Outcome results
None listed