Hyponatremia, SIAD - Syndrome of Inappropriate Antidiuresis
Conditions
Keywords
hyponatremia, SIAD, water load test
Brief summary
Acute water load test has been using to diagnose renal ability to excrete water for decades. Latest recommendations for the diagnosis of hyponatremia do not recommend performing such a test. The investigators aim at, retrospectively, study the value of acute water load test in patients suffering from a syndrome of inappropriate antidiuresis.
Interventions
PROCEDUREAcute water load test
The acute water load test consists in administering orally 20 mL/kg (of body weight) of water (ingested in less than 30 min) and then follow (during 4 to 6 hours) blood and urine parameters.
Sponsors
European Georges Pompidou Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥ 18 years old at the time of the test * affiliated to a social insurance system * water load test performed at the Renal and Metabolic Diseases Unit of the European George Pompidou Hospital, AP-HP, Paris, France * between 01/01/2001 and 12/31/2019
Exclusion criteria
* hypernatremia and/or polyuria-polydipsia (diabetes insipidus) * hyponatremia due to a tea and toast syndrome and/or a beer potomania * hyponatremia due to a high (or normal) osmolality related to diabetes mellitus, hyperproteinemia and/or intoxication * chronic kidney disease with an estimated glomerular filtration rate (eGFR) by the MDRD formula \<60 mL/min/1.73m2 * hyponatremia related to thiazides * hyponatremia related to an hypovolemic status * syndrome of inappropriate antidiuresis related to an endocrine disorder (such as hypothyroidism or adrenal insufficiency)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Natremia | any time after water load test from hour 2 to hour 6 | Plasma sodium concentration (abnormal if \<135mM) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma osmolality | any time after water load test from hour 2 to hour 6 | Plasma osmolality (abnormal if \<280mOsm/kgH2O) |
| Excretion of water load | after water load test from hour 0 to hour 6 | Ratio between the excreted water (in urine) volume and the ingested one |
| Urine osmolality | any time after water load test from hour 2 to hour 6 | Minimum urine osmolality reached |
Other
| Measure | Time frame | Description |
|---|---|---|
| Body weight | Value at hour 6 versus initial value (hour 0) | Variation of body weight during the test |
Countries
France
Outcome results
None listed